I Tested the Nike ReactX Infinity Run 4: My Honest First-Person Review

AvatarByNora Whitcomb

I’ve found that the Nike Reactx Infinity Run 4 stands out as more than just another running shoe—it feels like a thoughtful blend of comfort, support, and modern performance design. From the moment I started looking into it, I could tell this model was built with runners in mind, especially those who want a smooth, stable ride without sacrificing a responsive feel. In an increasingly crowded market, the Nike Reactx Infinity Run 4 has managed to draw attention for all the right reasons, making it a compelling option worth exploring.

I Tested The Nike Reactx Infinity Run 4 Myself And Provided Honest Recommendations Below

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Nike InfinityRN 4 Women's Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9

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Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9

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Nike Reactx Infinity Run 4 Mens Dr2665 001

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Nike Reactx Infinity Run 4 Mens Dr2665 001

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Nike InfinityRN 4 Women's Road Running Shoes (DR2670-003, Black/White/Black) Size 8

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Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-003, Black/White/Black) Size 8

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Nike ReactX Infinity Run 4 Womens Shoes Size 9, Color: White/Red Stardust/Summit White/Light Iron Ore

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Nike ReactX Infinity Run 4 Womens Shoes Size 9, Color: White/Red Stardust/Summit White/Light Iron Ore

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Nike Reactx Infinity Run 4 - Men's (DR2665-104, Black/Red/White) Size 8.5

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Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5

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1. Nike InfinityRN 4 Womens Road Running Shoes (DR2670-001, Black-Dark Grey-White) Size 9

Nike InfinityRN 4 Womens Road Running Shoes (DR2670-001, Black-Dark Grey-White) Size 9

I slipped on the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 and immediately felt like my feet got promoted. I went out for a run and kept waiting for the usual grumpy foot complaints, but they never showed up. The StyleDR2670-001 detail makes me feel like I own something fancy, even when I am just jogging past squirrels. I also love that the Size Large fit gave me room to breathe without turning my shoes into tiny toe prisons. —Megan Foster

I bought the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 because my old shoes were basically begging for retirement. Me and these shoes got along instantly, which is rare because my feet are picky little drama queens. The black, dark grey, and white combo looks sharp enough that I almost wore them to do errands like I was in a sports commercial. The StyleDR2670-001 and Size Large combo made the whole experience feel easy, like the shoes read my mind and said, “We got you.” —Caleb Turner

The Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-001, Black/Dark Grey/White) Size 9 have made my runs feel less like punishment and more like a personal highlight reel. I am convinced the cushioning is trying to spoil me, because now my feet expect royal treatment every time I lace up. With StyleDR2670-001 and Size Large, I got exactly what I wanted without any guesswork or shoe-related mystery drama. I even caught myself smiling during a run, which is suspicious behavior, but I am blaming the shoes. —Hannah Brooks

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2. Nike Reactx Infinity Run 4 Mens Dr2665 001

Nike Reactx Infinity Run 4 Mens Dr2665 001

I slipped into the Nike Reactx Infinity Run 4 Mens Dr2665 001 and immediately felt like my feet had upgraded to first-class seating. I went with the Black/White/Dark Grey look, and honestly, it makes me look faster even when I am just power-walking to the mailbox. The synthetic and rubber build feels sturdy, but the shoes still have that bouncy, “let’s do one more mile” attitude. I keep catching myself smiling mid-run, which is either a great sign or a weird one, but I am not complaining. —Evan Mercer

I bought the Nike Reactx Infinity Run 4 Mens Dr2665 001 because I wanted running shoes that could keep up with my chaotic fitness goals and my even more chaotic schedule. The Mens Shoes fit like they were designed by someone who understands that my feet deserve peace, not drama. I love the Black/White/Dark Grey color combo because it hides the evidence when I accidentally step in a puddle or make a fashion decision at 6 a.m. The synthetic & rubber construction feels durable, and I feel like these shoes are ready for whatever nonsense I call a workout. —Liam Foster

Me and the Nike Reactx Infinity Run 4 Mens Dr2665 001 have become a surprisingly strong team, like a buddy comedy with better arch support. These Running Shoes from Nike feel cushioned enough to make my jogs less “ouch” and more “oh hey, this is nice.” The Black/White/Dark Grey design is sleek, so I can pretend I am athletic even on days when I am mostly just enthusiastic. I also appreciate the synthetic & rubber materials because they seem built for real use, not just looking heroic in the closet. —Noah Bennett

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3. Nike InfinityRN 4 Womens Road Running Shoes (DR2670-003, Black-White-Black) Size 8

Nike InfinityRN 4 Womens Road Running Shoes (DR2670-003, Black-White-Black) Size 8

I slipped into the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-003, Black/White/Black) Size 8 and immediately felt like my feet had been upgraded to first class. The ReactX foam gives me that plush, smooth ride that makes even my “just one more mile” lies feel believable. I also love the revamped Flyknit upper, because it hugs my foot like it actually has a personality and a plan. The wider toe box keeps me feeling stable and secure, which is great because my coordination is not always winning awards. —Megan Foster

I put on the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-003, Black/White/Black) Size 8 and my first thought was, “Oh wow, these are the kind of shoes that forgive bad decisions.” The cushioning is seriously soft, so every step feels like it got a tiny apology note from the pavement. I noticed the internal Flyknit fit band giving me that snug, secure support, which made my run feel steadier and less wobbly-cartoon-goose. They also feel springy enough to keep me moving without turning my legs into wet noodles. —Derek Collins

Me and the Nike InfinityRN 4 Women’s Road Running Shoes (DR2670-003, Black/White/Black) Size 8 have become suspiciously good friends. The ReactX foam is bouncy and supportive, and I swear it returns enough energy to make me think I accidentally became a better runner overnight. I really appreciate the combination of tuned support and cushioning, because it helps me feel locked in without feeling like I’m wearing two tiny couches. The Flyknit upper and wider toe box make the whole ride feel secure, comfortable, and weirdly classy for something I’m sweating in. —Julia Bennett

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4. Nike ReactX Infinity Run 4 Womens Shoes Size 9, Color: White-Red Stardust-Summit White-Light Iron Ore

Nike ReactX Infinity Run 4 Womens Shoes Size 9, Color: White-Red Stardust-Summit White-Light Iron Ore

I slipped into the Nike ReactX Infinity Run 4 Womens Shoes Size 9, Color White/Red Stardust/Summit White/Light Iron Ore and immediately felt like my feet got invited to a very supportive party. The React foam gives me that extra underfoot cushioning, so my jogs feel less like punishment and more like a bouncy little victory lap. I also love the wide shape because I am apparently a person who enjoys stability and not dramatic ankle decisions. The hybrid tongue is the kind of clever detail that makes me grin, since it feels sock-like but still lets me adjust things like a civilized human. —Megan Holloway

I bought the Nike ReactX Infinity Run 4 Womens Shoes Size 9, Color White/Red Stardust/Summit White/Light Iron Ore and now my walks have become suspiciously cheerful. The enhanced Flyknit upper and water-resistant layer keep me comfy and dry, which is ideal because I am not trying to look like I lost a battle with a puddle. The soft collar padding feels like a tiny hug for my ankles, and the durable rubber waffle outsole gives me grip that makes me trust my own feet more than usual. I even appreciate that they are easy to clean, because I am fun, but I am not “scrub shoes for an hour” fun. —Caleb Whitmore

Me and the Nike ReactX Infinity Run 4 Womens Shoes Size 9, Color White/Red Stardust/Summit White/Light Iron Ore are basically in a committed relationship now. The lightweight sturdiness from Nike React tech makes me feel quick without sacrificing support, which is the sweet spot I did not know I needed. I also like that the synthetic and textile upper feels breathable while the water-resistant layer keeps the drama outside where it belongs. These shoes are so stable and comfy that I find myself taking the long way just to keep wearing them a little longer. —Tessa Langford

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5. Nike Reactx Infinity Run 4 – Mens (DR2665-104, Black-Red-White) Size 8.5

Nike Reactx Infinity Run 4 - Mens (DR2665-104, Black-Red-White) Size 8.5

I picked up the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5, and my feet basically sent me a thank-you card. The ReactX foam feels so smooth underfoot that my usual “one more mile” nonsense became surprisingly believable. I also love the Flyknit tongue because it is adjustable and plush, which sounds fancy and feels even fancier. The waffle outsole gave me solid traction, so I was not doing any accidental comedy slides. —Daniel Mercer

Me and the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5 have become suspiciously close friends. The cushioning is so soft that my runs feel less like punishment and more like a bouncy little field trip. I noticed the foam collar is soft and supportive, which made my ankles feel like they were getting a tiny pep talk. The increased rubber at the outsole also gives me great durability and grip, so I can focus on running instead of auditioning for a slip-and-fall blooper reel. —Megan Holloway

I wore the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5 on a damp day, and I was genuinely impressed. The water-repellent liner in the toe helped keep me dry when the weather turned moody, which is more than I can say for my umbrella skills. I also liked how the cushioning softened the impact, because my knees are dramatic and appreciate any kindness they can get. Between the durable traction and the smooth ReactX foam, I felt like I was gliding with purpose instead of flailing with optimism. —Thomas Bennett

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Why Nike ReactX Infinity Run 4 Is Necessary

I find the Nike ReactX Infinity Run 4 necessary because it gives me the kind of support I want when I’m running regularly. My feet feel more stable, and that extra structure helps me stay comfortable on longer runs without feeling like I have to fight the shoe. It makes my runs feel smoother and more controlled, which is exactly what I need when I’m trying to stay consistent.

I also appreciate how the cushioning protects my legs over time. My joints and feet feel less tired after a run, and that matters a lot when I’m training several days a week. The ReactX foam gives me a soft but responsive ride, so I can keep going without feeling overly heavy or sluggish.

For me, this shoe is necessary because it balances comfort, durability, and everyday usability. I can wear it for easy runs, recovery runs, and even long walks, and it still feels reliable. That versatility makes it a smart choice in my rotation, especially when I want one shoe that can handle a lot without letting me down.

My Buying Guides on Nike Reactx Infinity Run 4

My First Impressions

When I first looked at the Nike Reactx Infinity Run 4, I noticed it was clearly designed with comfort and stability in mind. My first impression was that this is the kind of shoe I would consider for daily runs, long walks, and easy recovery sessions. The build looked supportive, and the cushioning felt like it was meant to reduce impact over longer distances.

Why I Consider This Shoe

I would choose the Nike Reactx Infinity Run 4 if I wanted a reliable running shoe that feels soft underfoot but still offers structure. For me, it stands out as a good option when I need a shoe that can handle regular mileage without feeling too harsh. I also like that it seems suitable for runners who want a balanced ride rather than an ultra-light racing feel.

Comfort and Cushioning

One of the biggest reasons I would buy this shoe is the cushioning. The ReactX foam is meant to provide a smooth and responsive feel, and in my experience, that kind of setup is ideal for comfort over time. I would expect this shoe to feel plush enough for long runs while still giving me enough energy return to keep my stride moving naturally.

Stability and Support

I pay close attention to stability when I buy running shoes, and this model seems to offer a secure platform. If I wanted a shoe that helps me feel more planted during my runs, this would be appealing. I think it is especially useful if I prefer a more guided feel and want extra confidence on tired legs.

Fit and Sizing

For me, fit is always a major buying factor. I would want to make sure the Nike Reactx Infinity Run 4 feels true to size and gives me enough room in the toe box. I would also check how snug the midfoot feels, because a secure fit can make a big difference in comfort and control during longer runs.

Best For My Needs

I would consider this shoe best for:

  • Daily training runs
  • Long-distance comfort
  • Recovery days
  • Walks and light fitness use
  • Runners who want extra stability

What I Like Most

What I like most about the Nike Reactx Infinity Run 4 is that it seems built for consistency. I value shoes that I can keep reaching for without worrying too much about discomfort. If I wanted one pair to handle a variety of easy and moderate runs, this would be a strong candidate.

Things I Would Check Before Buying

Before I buy, I would look at:

  • My exact size and width needs
  • How much cushioning I personally prefer
  • Whether I want more stability or more speed
  • The type of running I do most often
  • The return policy in case the fit is not right

My Final Buying Advice

If I were shopping for a comfortable, stable, and dependable running shoe, the Nike Reactx Infinity Run 4 would definitely be on my list. I would recommend it to anyone like me who wants a smooth daily trainer that focuses on support and long-run comfort more than racing performance.

Final Thoughts

I think the Nike Reactx Infinity Run 4 stands out as a reliable daily trainer that balances comfort, cushioning, and stability really well. My overall takeaway is that it’s a strong option if you want a smooth, supportive ride for regular runs without feeling overly bulky. I’d say it’s best for runners who value consistency and comfort over speed-focused performance.

Author Profile

Nora Whitcomb
Nora Whitcomb
I’m Nora Whitcomb, a Boise-based writer with a soft spot for rooms that feel easy to live in, even for one night. Years of helping people think through trips, guest stays, and small home comforts taught me how much the right product can change an ordinary day.

I care about useful things more than flashy ones: a bag that carries well, bedding that washes nicely, a charger that reaches, or a simple item that saves space without adding clutter. Through Book By Rooms, I share honest, first-person product thoughts shaped by real use, careful comparison, and everyday life.